Synthesis
ChemicalBook > CAS DataBase List > Ethyl diazoacetate

Ethyl diazoacetate

Synthesis
Product Name
Ethyl diazoacetate
CAS No.
623-73-4
Chemical Name
Ethyl diazoacetate
Synonyms
Ethyl 2-diazoacetate;Daae;Diazoacetic ester;Ethyl diazoate;diazoaceticester;diazoacetate soL;ETHYL DIAZOACETATE;Ethyl diazoethanoate;Ethylene Diazo Acetate;Diazoacetic acid ethyl
CBNumber
CB9241343
Molecular Formula
C4H6N2O2
Formula Weight
114.1
MOL File
623-73-4.mol
More
Less

Ethyl diazoacetate Property

Melting point:
-22 °C (lit.)
Boiling point:
140-141 °C/720 mmHg (lit.)
Density 
1.085 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.46(lit.)
Flash point:
115 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly)
form 
Oil
color 
Light Yellow to Orange
Merck 
13,3021
BRN 
107654
NIST Chemistry Reference
Ethyl diazoacetate(623-73-4)
More
Less

Safety

Hazard Codes 
Xn,F
Risk Statements 
5-10-22-40-67-65-48/20-38-11-63
Safety Statements 
36/37-62-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
AG5775000
HazardClass 
3.2
PackingGroup 
III
HS Code 
29270000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H242Heating may cause a fire

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E22201
Product name
Ethyl diazoacetate
Purity
contains ≥13 wt. % dichloromethane
Packaging
5g
Price
$34.3
Updated
2024/03/01
Sigma-Aldrich
Product number
E22201
Product name
Ethyl diazoacetate
Purity
contains ≥13 wt. % dichloromethane
Packaging
1kg
Price
$1730
Updated
2024/03/01
Sigma-Aldrich
Product number
752150
Product name
Ethyl diazoacetate solution
Purity
15% in toluene
Packaging
25ML
Price
$28.4
Updated
2024/03/01
Sigma-Aldrich
Product number
752150
Product name
Ethyl diazoacetate solution
Purity
15% in toluene
Packaging
100ML
Price
$73.6
Updated
2024/03/01
Sigma-Aldrich
Product number
E22201
Product name
Ethyl diazoacetate
Purity
contains ≥13 wt. % dichloromethane
Packaging
20g
Price
$101
Updated
2024/03/01
More
Less

Ethyl diazoacetate Chemical Properties,Usage,Production

Synthesis

Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate.
NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O

Chemical Properties

Liquid.

Uses

Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1

Uses

New Diazoacetate Formulations

Hazard

Flammable liquid that explodes when heated.

Safety Profile

Poison by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Can explode. Explodes on contact with tris(dimethy1amino) antimony. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.

Purification Methods

It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.]

More
Less

Ethyl diazoacetate Suppliers

HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10658
Advantage
60
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
More
Less

View Lastest Price from Ethyl diazoacetate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl Diazoacetate 623-73-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-01-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl diazoacetate 623-73-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Ethyl diazoacetate 623-73-4
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-05

623-73-4, Ethyl diazoacetateRelated Search:


  • Acetic acid, diazo-, ethyl ester
  • Daae
  • Diazoacetic acid ethyl ester
  • Diazoacetic ester
  • diazoaceticacid,ethylester
  • diazo-aceticaciethylester
  • diazoaceticester
  • Diazoessigsaeure-aethylester
  • Ethoxycarbonyldiazomethane
  • Ethyl 2-diazoacetate
  • Ethyl diazoethanoate
  • ETHYL DIAZOACETATE
  • Ethylene Diazo Acetate
  • ETHYL DIAZOACETATE ETHYL DIAZOETHANOATE
  • 2-Diazoacetic acid ethyl
  • Diazoacetic acid ethyl
  • Ethyl diazoate
  • Acetic acid, 2-diazo-,ethyl ester
  • Ethyl diazoacetate contains >=13 wt. % dichloroMethane
  • Ethyl diazoacetate solution, 95%
  • 2-Diazoacetic acid ethyl ester solution
  • Ethyl diazoacetate solution,90% wt in dichloromethane
  • (e)-2-diazonio-1-ethoxyethenolate
  • Ethyl 2-diazoacetate (diluted with ~10% dichloromethane, wt/wt)
  • Ethyl diazoacetate, 95%, contains 5% CH2Cl2
  • diazoacetate soL
  • Ethyl Diazoacetate (&gt
  • Ethyl diazoacetate ISO 9001:2015 REACH
  • Ethyl Diazoacetate (>90%)
  • Ethyldiazoacetate, contains 15 wt. % dichloromethane
  • Ethyl diazoacetate 15% solution in DCM
  • Cilastatin Impurity 10
  • Tenofovir Disoproxil Fumarate Impurity 186
  • Ethyl diazoacetate, 80% solution in DCM
  • 623-73-4
  • N2CHCOOC2H5
  • NNCHCOOC2H5
  • Azo/Diazo Compounds
  • Building Blocks
  • Nitrogen Compounds
  • Organic Building Blocks
  • Azo/Diazo Compounds
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Carboxylic
  • Azo/Diazo Compounds
  • Nitrogen Compounds
  • Organic Building Blocks